DeepEn One™
Application
Blood flow tracking
Measuring blood flow dynamics in individual blood vessels, with applications across neuroscience and specific biomedical fields, such as stroke research.
The holographic microendoscope enables high-resolution in vivo imaging of fluorescently labelled blood vessels (e.g., with FITC-dextran. Using line-scan imaging at ~1 kHz, the researchers captured red blood cell traces to derive blood-flow velocity profiles and power spectra, which showed characteristic peaks from heart rate, respiration, and slow (<0.1 Hz) vascular oscillations linked to neurovascular coupling. A comparison between straight-view and side-view probe geometries showed that the side-view design caused significantly less disturbance to local blood flow, demonstrating its advantage for minimally invasive vascular imaging.
Source: Stibůrek, M., Ondráčková, P., Tučková, T. et al. 110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics. Nat Commun 14, 1897 (2023). https://doi.org/10.1038/s41467-023-36889-z
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